Chapter 3 . 1 Radiation dose of the novel P - gp tracer [ 11 C ] laniquidar
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چکیده
Resistance to current drug therapy is an important issue in the treatment of epilepsy. Inadequate access of central nervous system drugs to their targets in the brain may be caused by overexpression or overactivity of multidrug transporters, such as P-glycoprotein (P-gp), at the blood-brain barrier. Laniquidar, an inhibitor of P-gp, has been labeled with carbon-11 for the use in PET studies of P-gp expression in humans. Given potential interspecies diff erences in biodistribution, the purpose of this study was to ensure safe use of [C]laniquidar by determining the dosimetry of [C]laniquidar using whole body positron emission tomography (PET) studies.
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Chapter 3 . 2 Quantifi cation of [ 11 C ] laniquidar kinetics in the brain
Overexpression of the multidrug effl ux transport P-glycoprotein may play an important role in pharmacoresistance. [C]laniquidar is a newly developed tracer of P-glycoprotein expression. The aim of this study was to develop a pharmacokinetic model for quantifi cation of [C]laniquidar uptake and to assess its test-retest variability. methods Two (test-retest) dynamic [C]laniquidar PET scans were...
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UNLABELLED Overexpression of the multidrug efflux transport P-glycoprotein may play an important role in pharmacoresistance. (11)C-laniquidar is a newly developed tracer of P-glycoprotein expression. The aim of this study was to develop a pharmacokinetic model for quantification of (11)C-laniquidar uptake and to assess its test-retest variability. METHODS Two (test-retest) dynamic (11)C-laniq...
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